Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor. [electronic resource]
Producer: 20091217Description: 86-92 p. digitalISSN:- 1879-0542
- Antibodies, Blocking -- immunology
- Antibody Affinity
- Antigens, Neoplasm -- immunology
- Binding, Competitive
- Clone Cells
- Epitopes
- Graft vs Host Disease -- immunology
- HLA-A Antigens -- genetics
- HLA-A2 Antigen
- Humans
- Immunoglobulin Fab Fragments -- immunology
- Mutagenesis, Site-Directed
- Mutation
- Neoplasm Proteins -- immunology
- Peptide Fragments -- immunology
- Peptide Library
- Protein Binding
- Receptors, Antigen, T-Cell -- immunology
- Repressor Proteins -- immunology
- T-Cell Antigen Receptor Specificity
- T-Lymphocytes, Cytotoxic -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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