Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. [electronic resource]
Producer: 20091207Description: 2404-19 p. digitalISSN:- 1740-634X
- Animals
- Anti-Anxiety Agents -- pharmacology
- Antidepressive Agents -- pharmacology
- Anxiety -- drug therapy
- CREB-Binding Protein -- metabolism
- Dentate Gyrus -- drug effects
- Depression -- drug therapy
- Hippocampus -- drug effects
- Male
- Mice
- Mice, Inbred ICR
- Neurogenesis -- drug effects
- Neurons -- drug effects
- Phosphodiesterase 4 Inhibitors
- Phosphodiesterase Inhibitors -- pharmacology
- Prefrontal Cortex -- drug effects
- Rolipram -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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