Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. [electronic resource]
Producer: 20090922Description: 2193-6 p. digitalISSN:- 1528-0020
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid -- pharmacology
- Amino Acid Motifs -- genetics
- Animals
- Blood Platelets -- enzymology
- Enzyme Activation -- drug effects
- Fibrinogen -- metabolism
- Isoenzymes -- genetics
- Mice
- Mice, Knockout
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphorylation -- drug effects
- Platelet Adhesiveness -- drug effects
- Platelet Aggregation -- drug effects
- Platelet Glycoprotein GPIIb-IIIa Complex -- genetics
- Platelet Membrane Glycoproteins -- genetics
- Proto-Oncogene Proteins c-akt -- genetics
- Purinergic P2 Receptor Agonists
- Receptors, Purinergic P2 -- genetics
- Signal Transduction -- drug effects
- Vasoconstrictor Agents -- pharmacology
- rap GTP-Binding Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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