Podophyllin, but not the constituents quercetin or kaempferol, induced genotoxicity in vitro and in vivo through ROS production. [electronic resource]
Producer: 20090902Description: 68-76 p. digitalISSN:- 1525-6014
- Animals
- Chromosome Aberrations -- drug effects
- Dose-Response Relationship, Drug
- Kaempferols -- isolation & purification
- Male
- Mice
- Mice, Inbred ICR
- Micronuclei, Chromosome-Defective -- drug effects
- Mutagenicity Tests
- Mutagens -- chemistry
- Podophyllin -- administration & dosage
- Podophyllotoxin -- isolation & purification
- Quercetin -- isolation & purification
- Rats
- Rats, Wistar
- Reactive Oxygen Species -- metabolism
- Reticulocytes -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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