The MDM2-a splice variant of MDM2 alters transformation in vitro and the tumor spectrum in both Arf- and p53-null models of tumorigenesis. [electronic resource]
Producer: 20090918Description: 863-9 p. digitalISSN:- 1557-3125
- Animals
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cell Transformation, Neoplastic -- chemically induced
- Cyclin-Dependent Kinase Inhibitor p16 -- deficiency
- Disease Models, Animal
- Ethylnitrosourea
- Female
- Fibroblasts -- metabolism
- Male
- Mammary Neoplasms, Experimental -- chemically induced
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Neoplasms, Germ Cell and Embryonal -- chemically induced
- Protein Isoforms
- Proto-Oncogene Proteins c-mdm2 -- biosynthesis
- Tumor Suppressor Protein p53 -- deficiency
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Publication Type: Journal Article
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