Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s. [electronic resource]
Producer: 20090903Description: 220-6 p. digitalISSN:- 1872-7786
- Antipsychotic Agents -- pharmacokinetics
- Biotransformation
- Chlorpromazine -- pharmacokinetics
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2D6 -- metabolism
- Cytochrome P-450 CYP2D6 Inhibitors
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacology
- Glutathione -- metabolism
- Humans
- In Vitro Techniques
- Microsomes, Liver -- enzymology
- Quinidine -- pharmacology
- Quinones -- pharmacokinetics
- Tandem Mass Spectrometry
- Thioridazine -- pharmacokinetics
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Publication Type: Journal Article
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