Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. [electronic resource]
Producer: 20090814Description: 1940-51 p. digitalISSN:- 1551-4005
- Animals
- Anthracyclines -- chemistry
- Antineoplastic Agents -- chemistry
- Boronic Acids -- chemistry
- Bortezomib
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Chymotrypsin -- antagonists & inhibitors
- Cyclin-Dependent Kinase Inhibitor p27
- Drug Discovery
- Humans
- Inhibitory Concentration 50
- Intracellular Signaling Peptides and Proteins -- agonists
- Mice
- Mice, Nude
- Neoplasms -- enzymology
- Proteasome Inhibitors
- Protein Conformation
- Pyrazines -- chemistry
- Serine Proteinase Inhibitors -- chemistry
- Small Molecule Libraries
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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