Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. [electronic resource]
Producer: 20090812Description: H65-75 p. digitalISSN:- 1522-1539
- Alleles
- Animals
- Aortic Valve Stenosis -- diagnostic imaging
- Blood Pressure -- physiology
- Calcinosis -- diagnostic imaging
- Echocardiography
- ErbB Receptors -- genetics
- Female
- Heart Failure -- etiology
- Heart Function Tests
- Heart Valves -- diagnostic imaging
- Hypertrophy, Left Ventricular -- diagnostic imaging
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Phosphorylation
- RNA, Messenger -- biosynthesis
- Reverse Transcriptase Polymerase Chain Reaction
- Species Specificity
- Survival
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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