Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants. [electronic resource]
Producer: 20100709Description: 291-8 p. digitalISSN:- 1573-0646
- Androgen Antagonists -- chemical synthesis
- Androgen Receptor Antagonists
- Antineoplastic Agents, Hormonal -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chalcones -- chemical synthesis
- Drug Design
- Drug Resistance, Neoplasm -- genetics
- Drug Screening Assays, Antitumor
- Humans
- Male
- Molecular Structure
- Mutation -- drug effects
- Norisoprenoids -- chemical synthesis
- Receptors, Androgen -- genetics
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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