Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. [electronic resource]
Producer: 19910926Description: 15882-9 p. digitalISSN:- 0021-9258
- Animals
- Antineoplastic Agents -- metabolism
- Colchicine -- pharmacology
- Depsipeptides
- Drug Screening Assays, Antitumor
- Ethers, Cyclic -- metabolism
- Guanosine Triphosphate -- metabolism
- Hydrolysis
- Leukemia L1210
- Macrolides
- Maytansine -- pharmacology
- Microtubules -- drug effects
- Mitosis -- drug effects
- Oligopeptides -- pharmacology
- Polymers
- Porifera
- Tubulin -- drug effects
- Vinblastine -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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