Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. [electronic resource]
Producer: 20090602Description: 3047-62 p. digitalISSN:- 1520-4804
- Administration, Oral
- Animals
- Cell Line
- Constriction, Pathologic -- chemically induced
- Disease Models, Animal
- Drug Discovery
- Enzyme Inhibitors -- administration & dosage
- Fluoroquinolones -- administration & dosage
- Formaldehyde -- toxicity
- Humans
- Inhibitory Concentration 50
- Lipopolysaccharides -- toxicity
- Mice
- Nitric Oxide Synthase Type II -- antagonists & inhibitors
- Pain -- drug therapy
- Protein Multimerization -- drug effects
- Protein Structure, Quaternary
- Pyrazines -- administration & dosage
- Quinolones -- administration & dosage
- Structure-Activity Relationship
- Substrate Specificity
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Publication Type: Journal Article
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