Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. [electronic resource]
Producer: 20090707Description: 1709-20 p. digitalISSN:- 1879-0852
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical -- methods
- Humans
- Mice
- Mice, SCID
- Mice, Transgenic
- Neurilemmoma -- metabolism
- Neuroma, Acoustic -- metabolism
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyrazoles -- pharmacology
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- Schwann Cells -- cytology
- Signal Transduction -- drug effects
- Sulfonamides -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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