Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region. [electronic resource]
Producer: 19910918Description: 4139-45 p. digitalISSN:- 0305-1048
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Binding Sites
- DNA-Binding Proteins -- genetics
- Enhancer Elements, Genetic -- physiology
- Gene Expression Regulation -- physiology
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 3-alpha
- Hepatocyte Nuclear Factor 3-beta
- Hepatocyte Nuclear Factor 4
- Humans
- Mice
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis, Site-Directed -- physiology
- Nuclear Proteins -- genetics
- Phosphoproteins
- Prealbumin -- genetics
- Promoter Regions, Genetic -- physiology
- Transcription Factors -- genetics
- Transfection -- genetics
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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