MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. [electronic resource]
Producer: 20090707Description: 13987-4000 p. digitalISSN:- 0021-9258
- Animals
- Apoptosis
- Cell Line
- Cell Nucleus -- metabolism
- Cytoprotection
- Forkhead Transcription Factors -- metabolism
- Gene Expression Regulation
- Humans
- Mice
- Phosphorylation
- Protein Binding
- Protein Processing, Post-Translational
- Protein Transport
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-mdm2 -- chemistry
- Tumor Suppressor Protein p53 -- metabolism
- Ubiquitin-Protein Ligases -- metabolism
- Ubiquitination
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Publication Type: Journal Article
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