The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. [electronic resource]
Producer: 20090424Description: 964-75 p. digitalISSN:- 1558-8238
- Animals
- Base Sequence
- Cyclin-Dependent Kinase Inhibitor p16 -- deficiency
- DNA Primers -- genetics
- Gammaretrovirus -- genetics
- Genes, p16
- Genetic Therapy -- adverse effects
- Genetic Vectors -- adverse effects
- Hematopoietic Stem Cell Transplantation -- adverse effects
- Lentivirus -- genetics
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Neoplasms, Experimental -- etiology
- Terminal Repeat Sequences
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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