Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. [electronic resource]
Producer: 20090730Description: 1937-50 p. digitalISSN:- 1460-2083
- Androgens -- metabolism
- Animals
- Autophagy
- Cell Line
- Cell Nucleus -- genetics
- Cells, Cultured
- Cytoplasm -- genetics
- Disease Models, Animal
- Humans
- Male
- Mice
- Mice, Transgenic
- Motor Activity
- Motor Neurons -- cytology
- Muscular Atrophy, Spinal -- genetics
- Nuclear Localization Signals -- genetics
- Peptides -- genetics
- Protein Transport
- Receptors, Androgen -- genetics
- Trinucleotide Repeat Expansion
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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