Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. [electronic resource]
Producer: 20090814Description: 2105-14 p. digitalISSN:- 1097-4547
- Alzheimer Disease -- genetics
- Aminoquinolines -- pharmacology
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- biosynthesis
- Animals
- Cell Line
- Cells, Cultured
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Gene Expression Regulation -- drug effects
- Hippocampus -- cytology
- Humans
- Mice
- Mice, Inbred ICR
- Neurons -- drug effects
- Peptide Fragments -- metabolism
- Promoter Regions, Genetic -- genetics
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors
- Pyrimidines -- pharmacology
- RNA, Messenger -- drug effects
- RNA, Small Interfering -- genetics
- Transcription, Genetic -- drug effects
- Transfection
- rac1 GTP-Binding Protein -- antagonists & inhibitors
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Publication Type: Journal Article
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