Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. [electronic resource]
Producer: 20090609Description: 305-15 p. digitalISSN:- 1470-8728
- Animals
- Blotting, Western
- Cell Line
- Cell Proliferation -- drug effects
- Cholesterol -- metabolism
- Chromatography, High Pressure Liquid
- DNA-Binding Proteins -- metabolism
- Desmosterol -- metabolism
- HeLa Cells
- Humans
- Hydroxycholesterols -- pharmacology
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Liver X Receptors
- Lovastatin -- pharmacology
- Macrophages -- cytology
- Mice
- Nerve Tissue Proteins -- deficiency
- Orphan Nuclear Receptors
- Oxidoreductases Acting on CH-CH Group Donors -- deficiency
- RNA, Messenger -- genetics
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Sterol Regulatory Element Binding Protein 1 -- metabolism
- Sterol Regulatory Element Binding Protein 2 -- metabolism
- Sterols -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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