Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells. [electronic resource]
Producer: 20090623Description: 1063-70 p. digitalISSN:- 1521-0103
- Aniline Compounds -- pharmacology
- Apoptosis -- drug effects
- Benzamides -- pharmacology
- Butadienes -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor -- drug effects
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm -- physiology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Humans
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Nitriles -- pharmacology
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-raf -- genetics
- RNA, Small Interfering -- genetics
- Signal Transduction -- drug effects
- Trans-Activators -- metabolism
- Tumor Suppressor Protein p53 -- metabolism
- Up-Regulation -- physiology
- Viral Regulatory and Accessory Proteins -- metabolism
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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