Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. [electronic resource]
Producer: 20090707Description: 699-707 p. digitalISSN:- 1520-5010
- Acetaminophen -- toxicity
- Animals
- Carnitine -- analogs & derivatives
- Chemical and Drug Induced Liver Injury
- Chromatography, Liquid
- Cytochrome P-450 CYP2E1 -- deficiency
- Fatty Acids -- metabolism
- Glutathione -- metabolism
- Liver Diseases -- metabolism
- Mass Spectrometry
- Metabolomics
- Mice
- Mice, Knockout
- PPAR alpha -- antagonists & inhibitors
- Time Factors
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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