Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism. [electronic resource]
Producer: 20090602Description: 4300-8 p. digitalISSN:- 1528-0020
- Adult
- Aged
- Aged, 80 and over
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Apoptosis
- Blotting, Western
- Carbamates -- pharmacology
- Cell Differentiation
- Dipeptides -- pharmacology
- Drug Synergism
- Drug Therapy, Combination
- Feedback, Physiological
- Female
- HL-60 Cells
- Humans
- Imidazoles -- pharmacology
- Leukemia, Lymphocytic, Chronic, B-Cell -- genetics
- Male
- Middle Aged
- Osteoclasts -- cytology
- Piperazines -- pharmacology
- RNA, Messenger -- metabolism
- Receptor, Notch1 -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Stereoisomerism
- Tumor Suppressor Protein p53 -- antagonists & inhibitors
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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