Pentobarbital produces activation and block of {alpha}1{beta}2{gamma}2S GABAA receptors in rapidly perfused whole cells and membrane patches: divergent results can be explained by pharmacokinetics. [electronic resource]
Producer: 20090318Description: 171-88 p. digitalISSN:- 1540-7748
- Animals
- Binding Sites
- Cell Compartmentation
- Dose-Response Relationship, Drug
- Feedback, Physiological -- drug effects
- GABA Modulators -- pharmacology
- GABA-A Receptor Agonists
- GABA-A Receptor Antagonists
- Humans
- Intracellular Space -- drug effects
- Ion Channel Gating -- drug effects
- Ion Transport -- drug effects
- Models, Biological
- Patch-Clamp Techniques
- Pentobarbital -- pharmacology
- Pharmacokinetics
- Protein Subunits -- drug effects
- Rats
- Receptors, GABA-A -- drug effects
- Research Design
- gamma-Aminobutyric Acid -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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