Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. [electronic resource]
Producer: 20090219Description: e17 p. digitalISSN:- 1545-7885
- 3-Phosphoinositide-Dependent Protein Kinases
- Allosteric Regulation -- physiology
- Animals
- Binding Sites -- drug effects
- Gene Expression Regulation
- Mice
- Mutagenesis
- Phosphorylation
- Protein Conformation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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