A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts. [electronic resource]
Producer: 20090327Description: 1024-35 p. digitalISSN:- 1742-4658
- Animals
- Cells, Cultured
- Dual Specificity Phosphatase 6 -- physiology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Feedback, Physiological
- Fibroblasts -- metabolism
- Genes, ras
- Humans
- MAP Kinase Signaling System -- physiology
- Mice
- Models, Biological
- Oligonucleotide Array Sequence Analysis
- Phosphorylation
- RNA Stability
- RNA, Messenger -- metabolism
- Rats
- Signal Transduction -- physiology
- Systems Biology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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