The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. [electronic resource]
Producer: 20090428Description: 38-47 p. digitalISSN:- 1521-0103
- Antineoplastic Agents, Phytogenic -- pharmacology
- Blotting, Western
- Cell Division -- drug effects
- Cell Membrane -- drug effects
- Cell Nucleus -- drug effects
- Cyclophilin A -- metabolism
- Cytoplasm -- drug effects
- Electrophoresis, Polyacrylamide Gel
- Flow Cytometry
- G2 Phase -- drug effects
- Hematologic Neoplasms -- metabolism
- Humans
- Hydrolysis
- Microtubules -- drug effects
- Monocytes -- drug effects
- NIMA-Interacting Peptidylprolyl Isomerase
- Oxazepines -- pharmacology
- Paclitaxel -- pharmacology
- Peptide Mapping
- Peptidylprolyl Isomerase -- metabolism
- Pyrroles -- pharmacology
- Silver Staining
- Trypsin -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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