Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. [electronic resource]
Producer: 19910521Description: 1460-7 p. digitalISSN:- 0022-2623
- 4-Butyrolactone -- analogs & derivatives
- Alkylation
- Animals
- Anticonvulsants -- chemical synthesis
- Brain -- metabolism
- Convulsants -- chemical synthesis
- Female
- Ligands
- Mice
- Mice, Inbred Strains
- Molecular Structure
- Neurotoxins -- chemical synthesis
- Picrotoxin -- metabolism
- Receptors, GABA-A -- drug effects
- Seizures -- physiopathology
- Structure-Activity Relationship
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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