A novel reciprocal and biphasic relationship between membrane cholesterol and beta-secretase activity in SH-SY5Y cells and in human platelets. [electronic resource]
Producer: 20090408Description: 341-9 p. digitalISSN:- 1471-4159
- Aged
- Aged, 80 and over
- Alzheimer Disease -- blood
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Aspartic Acid Endopeptidases -- metabolism
- Blood Platelets -- cytology
- Case-Control Studies
- Cell Line, Tumor
- Cell Membrane -- drug effects
- Cholesterol -- metabolism
- Cognition Disorders -- blood
- Culture Media, Serum-Free -- pharmacology
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay -- methods
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Linear Models
- Male
- Neuroblastoma -- pathology
- Statistics, Nonparametric
- Subcellular Fractions
- Time Factors
- beta-Cyclodextrins -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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