p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway. [electronic resource]
Producer: 20090320Description: 143-51 p. digitalISSN:- 1872-7980
- Aspartic Acid -- analogs & derivatives
- Genes, p53
- HCT116 Cells
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- analysis
- Mutation
- Neoplasms -- blood supply
- Reactive Oxygen Species -- metabolism
- Signal Transduction
- Tumor Suppressor Protein p53 -- analysis
- Vascular Endothelial Growth Factor A -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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