Synthesis and biological evaluation of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504), a dual inhibitor of TXA2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS). [electronic resource]
Producer: 19910403Description: 173-6 p. digitalISSN:- 0732-8141
- 6-Ketoprostaglandin F1 alpha -- biosynthesis
- Animals
- Antioxidants -- chemical synthesis
- Benzoquinones -- chemical synthesis
- Drug Design
- Drug Evaluation, Preclinical
- Free Radicals
- Glomerulonephritis -- chemically induced
- Humans
- Leukotriene B4 -- biosynthesis
- Lipoxygenase Inhibitors
- Molecular Structure
- Oxygen -- metabolism
- Puromycin Aminonucleoside -- toxicity
- Rats
- Structure-Activity Relationship
- Thromboxane B2 -- biosynthesis
- Thromboxane-A Synthase -- antagonists & inhibitors
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Publication Type: Journal Article
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