Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. [electronic resource]
Producer: 19910312Description: 98-107 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Camptothecin -- analogs & derivatives
- Cattle
- Cell Line
- Colonic Neoplasms -- drug therapy
- DNA, Superhelical -- drug effects
- Drug Evaluation, Preclinical
- Drug Screening Assays, Antitumor
- Humans
- Indicators and Reagents
- Leukemia L1210 -- drug therapy
- Lung Neoplasms -- drug therapy
- Melanoma, Experimental -- drug therapy
- Mice
- Molecular Structure
- Plasmids
- Structure-Activity Relationship
- Thymus Gland -- enzymology
- Topoisomerase I Inhibitors
- Transplantation, Heterologous
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Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
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