Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction. [electronic resource]
Producer: 20090303Description: 11-24 p. digitalISSN:- 1744-6872
- Antifungal Agents -- pharmacology
- Base Sequence
- Cell Line
- Cytochrome P-450 CYP3A -- genetics
- Cytochrome P-450 CYP3A Inhibitors
- DNA Primers -- genetics
- Gene Expression Regulation, Enzymologic -- drug effects
- HeLa Cells
- Hepatocyte Nuclear Factor 4 -- antagonists & inhibitors
- Histone Acetyltransferases -- antagonists & inhibitors
- Humans
- In Vitro Techniques
- Ketoconazole -- pharmacology
- Ligands
- Nuclear Receptor Coactivator 1
- Pharmacogenetics
- Pregnane X Receptor
- Promoter Regions, Genetic
- Protein Interaction Domains and Motifs
- RNA Interference
- Receptors, Steroid -- antagonists & inhibitors
- Recombinant Proteins -- antagonists & inhibitors
- Rifampin -- pharmacology
- Transcription Factors -- antagonists & inhibitors
- Two-Hybrid System Techniques
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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