Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. [electronic resource]
Producer: 20090407Description: R104 p. digitalISSN:- 1465-542X
- Animals
- Annexin A5 -- metabolism
- Antimetabolites, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Breast Neoplasms -- drug therapy
- Buthionine Sulfoximine -- pharmacology
- Cell Proliferation -- drug effects
- Cytochromes c -- metabolism
- Drug Resistance, Neoplasm
- Drug Synergism
- Estradiol -- pharmacology
- Estrogens -- deficiency
- Female
- Forkhead Transcription Factors -- physiology
- Glutathione -- metabolism
- Humans
- Immunoenzyme Techniques
- In Situ Nick-End Labeling
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Membrane Potential, Mitochondrial -- drug effects
- Mice
- Mice, Nude
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- RNA, Messenger -- genetics
- RNA, Small Interfering -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Cells, Cultured
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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