The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. [electronic resource]
Producer: 20090204Description: 640-9 p. digitalISSN:- 1098-5549
- Animals
- Carrier Proteins -- metabolism
- Cell Line
- Cell Proliferation -- drug effects
- Gene Expression Regulation -- drug effects
- Humans
- Insulin -- pharmacology
- Mice
- Mitosis -- drug effects
- Monomeric GTP-Binding Proteins -- metabolism
- Neuropeptides -- metabolism
- Protein Biosynthesis -- drug effects
- Protein Kinases -- deficiency
- RNA 5' Terminal Oligopyrimidine Sequence -- genetics
- Rapamycin-Insensitive Companion of mTOR Protein
- Ras Homolog Enriched in Brain Protein
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
- Tacrolimus Binding Protein 1A -- metabolism
- Tuberous Sclerosis Complex 1 Protein
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- deficiency
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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