Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome. [electronic resource]
Producer: 20090528Description: 352-62 p. digitalISSN:- 1098-1004
- Abnormalities, Multiple -- genetics
- Cells, Cultured
- Chromones -- pharmacology
- Craniofacial Abnormalities
- Enzyme Inhibitors -- pharmacology
- Epidermal Growth Factor -- pharmacology
- Failure to Thrive -- pathology
- Fibroblasts -- drug effects
- Guanosine Triphosphate -- metabolism
- Humans
- Immunoblotting
- Intellectual Disability -- pathology
- MAP Kinase Kinase 1 -- metabolism
- MAP Kinase Kinase 2 -- metabolism
- Morpholines -- pharmacology
- Mutation
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins p21(ras) -- genetics
- Signal Transduction -- drug effects
- Skin -- drug effects
- Skin Abnormalities
- Syndrome
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Publication Type: Journal Article
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