Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. [electronic resource]
Producer: 20090403Description: 7352-5 p. digitalISSN:- 1520-4804
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Binding Sites
- Biomimetic Materials -- chemical synthesis
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Cyclization
- Dose-Response Relationship, Drug
- Drug Design
- Drug Evaluation, Preclinical
- Drug Screening Assays, Antitumor
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Inhibitor of Apoptosis Proteins -- antagonists & inhibitors
- Mitochondria -- enzymology
- Models, Molecular
- Molecular Conformation
- Molecular Weight
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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