Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients. [electronic resource]
Producer: 20090611Description: 971-4 p. digitalISSN:- 1476-5551
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Child
- Drug-Related Side Effects and Adverse Reactions
- Female
- Hematopoietic Stem Cell Transplantation
- Heterozygote
- Humans
- Male
- Mercaptopurine -- pharmacology
- Methylenetetrahydrofolate Reductase (NADPH2) -- genetics
- Methyltransferases -- genetics
- Mutation -- genetics
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- enzymology
- Retrospective Studies
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Publication Type: Letter
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