Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. [electronic resource]
Producer: 20090403Description: 7265-72 p. digitalISSN:- 1520-4804
- Administration, Oral
- Animals
- Biological Availability
- Caco-2 Cells
- Crystallography, X-Ray
- Cyclopropanes -- chemistry
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Design
- Humans
- Male
- Microsomes, Liver -- chemistry
- Milnacipran
- Models, Molecular
- Molecular Structure
- Molecular Weight
- Neuralgia -- drug therapy
- Norepinephrine Plasma Membrane Transport Proteins -- antagonists & inhibitors
- Pain Measurement -- drug effects
- Rats
- Rats, Sprague-Dawley
- Serotonin Plasma Membrane Transport Proteins -- metabolism
- Selective Serotonin Reuptake Inhibitors -- chemistry
- Spinal Nerves -- pathology
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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