A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Abeta-inhibition of the cascade in cultured rat CNS neurons. [electronic resource]
Producer: 20090327Description: 10-7 p. digitalISSN:- 1879-0712
- Alzheimer Disease -- drug therapy
- Amyloid beta-Peptides -- antagonists & inhibitors
- Animals
- Cells, Cultured
- Cerebral Cortex -- cytology
- Cyclic AMP -- metabolism
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- drug effects
- Dose-Response Relationship, Drug
- Extracellular Signal-Regulated MAP Kinases -- drug effects
- Mitogen-Activated Protein Kinases -- drug effects
- Neurons -- drug effects
- Phosphorylation -- drug effects
- Propiophenones -- administration & dosage
- Rats
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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