Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. [electronic resource]
Producer: 20090507Description: 231-42 p. digitalISSN:- 1476-5594
- Antibodies -- pharmacology
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Boronic Acids -- pharmacology
- Bortezomib
- Cell Adhesion -- physiology
- Cell Adhesion Molecules -- physiology
- Cell Line, Tumor -- metabolism
- Dexamethasone -- pharmacology
- Down-Regulation
- Doxorubicin -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Gene Knockdown Techniques
- Humans
- Integrin alpha Chains -- biosynthesis
- Integrin alpha4 -- biosynthesis
- Integrin alpha4beta1 -- physiology
- Multiple Myeloma -- drug therapy
- Neoplasm Proteins -- biosynthesis
- Pyrazines -- pharmacology
- Vincristine -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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