The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. [electronic resource]
Producer: 20090401Description: 253-63 p. digitalISSN:- 0006-3002
- Animals
- Antioxidants -- metabolism
- Apoptosis -- drug effects
- Carcinoma, Hepatocellular -- enzymology
- Epidermal Growth Factor -- metabolism
- ErbB Receptors -- antagonists & inhibitors
- Gene Expression Regulation, Neoplastic -- drug effects
- Isoenzymes -- genetics
- Liver Neoplasms -- enzymology
- Mitochondria -- drug effects
- NADH, NADPH Oxidoreductases -- genetics
- NADPH Oxidase 1
- NADPH Oxidase 4
- NADPH Oxidases -- genetics
- Oxidative Stress -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Quinazolines
- RNA, Small Interfering -- metabolism
- Rats
- Reactive Oxygen Species -- metabolism
- Transforming Growth Factor beta -- pharmacology
- Tyrphostins -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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