Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. [electronic resource]
Producer: 20090617Description: 309-17 p. digitalISSN:- 1090-2139
- Aging
- Analysis of Variance
- Animals
- Brain -- drug effects
- Cerebral Cortex -- immunology
- Enzyme-Linked Immunosorbent Assay
- Gene Expression Regulation
- Injections, Intraperitoneal
- Interleukin-10 -- blood
- Interleukin-1beta -- blood
- Lipopolysaccharides -- administration & dosage
- Male
- Mice
- Mice, Inbred BALB C
- Microglia -- drug effects
- Polymerase Chain Reaction
- RNA, Messenger -- metabolism
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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