IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. [electronic resource]
Producer: 20081216Description: 1635-40 p. digitalISSN:- 1462-0332
- Antibodies, Monoclonal -- pharmacology
- Antibodies, Monoclonal, Humanized
- Arthritis, Rheumatoid -- metabolism
- Blotting, Western -- methods
- Cell Proliferation -- drug effects
- Cells, Cultured
- Fibroblasts
- Flavonoids -- pharmacology
- Humans
- Immunohistochemistry
- Interleukin-17 -- pharmacology
- Interleukin-1beta -- pharmacology
- Interleukin-6 -- metabolism
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Phosphorylation -- drug effects
- RANK Ligand -- analysis
- RNA, Messenger -- analysis
- Receptor Activator of Nuclear Factor-kappa B -- metabolism
- Receptors, Interleukin-6 -- antagonists & inhibitors
- Recombinant Proteins -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- STAT3 Transcription Factor -- metabolism
- Sesquiterpenes -- pharmacology
- Signal Transduction -- physiology
- Stimulation, Chemical
- Synovial Membrane -- drug effects
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article
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