Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies. [electronic resource]
Producer: 20081030Description: 6021-33 p. digitalISSN:- 1520-4804
- Antiviral Agents -- chemical synthesis
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Drug Design
- Ethers, Cyclic -- chemical synthesis
- HIV Protease -- chemistry
- HIV Protease Inhibitors -- chemical synthesis
- HIV-1 -- drug effects
- Humans
- Hydrogen Bonding
- Ligands
- Microbial Sensitivity Tests
- Models, Molecular
- Molecular Structure
- Polyesters -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
- T-Lymphocytes -- drug effects
- Water -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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