Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. [electronic resource]
Producer: 20080930Description: 13568-73 p. digitalISSN:- 1091-6490
- Active Transport, Cell Nucleus
- Antineoplastic Agents -- pharmacology
- Base Sequence
- Cell Line, Tumor
- Cullin Proteins -- metabolism
- Down-Regulation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Kelch-Like ECH-Associated Protein 1
- Models, Molecular
- Mutation -- genetics
- NF-E2-Related Factor 2 -- chemistry
- Neoplasms -- genetics
- Oxidative Stress
- Protein Binding
- Protein Structure, Tertiary
- Substrate Specificity
- Transcription, Genetic -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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