CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. [electronic resource]
Producer: 20081002Description: 6669-79 p. digitalISSN:- 1538-7445
- Amino Acids -- metabolism
- Aminopeptidases -- antagonists & inhibitors
- Animals
- Biomarkers, Tumor -- metabolism
- Cell Proliferation -- drug effects
- Electrophoresis, Polyacrylamide Gel
- Enzyme Inhibitors -- pharmacology
- Eukaryotic Initiation Factor-2 -- metabolism
- Gene Expression Profiling
- Gene Expression Regulation, Leukemic
- Glycine -- analogs & derivatives
- HL-60 Cells -- drug effects
- Humans
- Hydroxamic Acids -- pharmacology
- Immunoblotting
- Leucine -- analogs & derivatives
- Mice
- Oligonucleotide Array Sequence Analysis
- Peptide Fragments -- metabolism
- Phenylalanine -- analogs & derivatives
- Phosphorylation -- drug effects
- Protein Kinases -- metabolism
- Protein Synthesis Inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA, Messenger -- genetics
- Rats
- Reverse Transcriptase Polymerase Chain Reaction
- TOR Serine-Threonine Kinases
- Thiophenes -- pharmacology
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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