Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors. [electronic resource]
Producer: 20081202Description: 579-96 p. digitalISSN:- 1354-750X
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Biomarkers -- metabolism
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1
- Cyclin B -- metabolism
- Cyclin B1
- DNA Topoisomerases -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- administration & dosage
- Female
- Genetic Therapy -- methods
- HeLa Cells
- Histones -- metabolism
- Humans
- Male
- Mice
- Mice, SCID
- Mitosis -- drug effects
- Neoplasms -- drug therapy
- Phosphorylation
- Protein Kinase Inhibitors -- administration & dosage
- Protein Kinases -- genetics
- RNA Interference
- RNA, Small Interfering -- metabolism
- Time Factors
- Topoisomerase Inhibitors
- Transfection
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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