Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether. [electronic resource]
Producer: 20091113Description: 2234-43 p. digitalISSN:- 1521-009X
- Alkynes -- chemical synthesis
- Coumarins -- chemical synthesis
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inhibitors
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- chemical synthesis
- Ethers -- chemical synthesis
- Humans
- Imidazoles -- chemical synthesis
- Microsomes, Liver -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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