N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets. [electronic resource]
Producer: 20081118Description: 384-90 p. digitalISSN:- 1600-0609
- Amino Acid Substitution
- Animals
- Anti-Bacterial Agents -- pharmacology
- Binding Sites -- genetics
- Blood Platelets -- metabolism
- COS Cells
- Chlorocebus aethiops
- Collagen -- metabolism
- Crotalid Venoms -- pharmacology
- Factor VIII -- genetics
- Family
- Female
- Heterozygote
- Humans
- Male
- Mutation, Missense
- Pedigree
- Platelet Adhesiveness -- drug effects
- Platelet Aggregation -- drug effects
- Platelet Glycoprotein GPIb-IX Complex -- genetics
- Protein Binding -- drug effects
- Protein Structure, Tertiary -- genetics
- Ristocetin -- pharmacology
- von Willebrand Diseases -- genetics
- von Willebrand Factor -- genetics
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Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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