Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. [electronic resource]
Producer: 20080929Description: 5605-20 p. digitalISSN:- 1098-5549
- ADAM Proteins -- genetics
- ADAM17 Protein
- Antibodies, Monoclonal -- therapeutic use
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents -- therapeutic use
- Breast Neoplasms -- drug therapy
- Cells, Cultured
- Enzyme Activation
- Female
- Gene Expression Profiling
- Humans
- Oligonucleotide Array Sequence Analysis
- Phosphatidylinositol 3-Kinases -- genetics
- Proto-Oncogene Proteins c-akt -- genetics
- RNA Interference
- Receptor, ErbB-2 -- genetics
- Signal Transduction -- physiology
- Transforming Growth Factor alpha -- metabolism
- Transforming Growth Factor beta -- metabolism
- Trastuzumab
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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