The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias. [electronic resource]
Producer: 20081212Description: 1712-22 p. digitalISSN:- 1350-9047
- Animals
- Apoptosomes -- drug effects
- Autophagy -- drug effects
- Caspases -- metabolism
- Cell Line, Tumor
- Chloroquine -- pharmacology
- Cytoprotection -- drug effects
- Disease Models, Animal
- Enzyme Activation -- drug effects
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- enzymology
- Male
- Mice
- Mice, SCID
- Protein Kinase Inhibitors -- pharmacology
- Pyrimidines -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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